Subacute toxicity research in dogs for 4 weeks at 480 mg/kg day-to-day showed no specific modifications; at 960 mg/kg, two outside of 8 died with evidence of circulatory collapse. This large margin of protection is important as compared to chlordiazepoxide HCl, which showed nonspecific modifications in 6 canine at 80 mg/kg.Paradoxical reactions, su